Notes to Macbeth, Act 3, Scene 1, lines 115-117: "and in such bloody distance, / That every minute of his being thrusts / Against my near'st of life"


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Macbeth,
Act 3, Scene 1, line 115.
This passage contains a fencing metaphor. The "distance" is the gap between them maintained by the combatants in a fencing match, so a "bloody distance" is one which would allow one of the fencers to draw blood. And "thrusts / Against my near'st of life" means "strikes at my heart."